Djedkhonsuefankh was an important ancient Egyptian religious figure who served as the High Priest of Amun in Thebes during the late Twenty‑first Dynasty, around 1046–1045 BC. As High Priest, he was one of the most powerful religious leaders in southern Egypt at a time when the priesthood of Amun held significant political as well as spiritual influence.

Although his tenure was very short—only about a year—he succeeded his brother Masaharta and was followed by another brother, Menkheperre, which suggests he came from a prominent priestly family linked to the powerful ruler‑priest Pinedjem I.

The only evidence of his existence comes from an inscription on his son’s now‑lost coffin, which identifies him as “the first prophet of Amun” and connects him to the influential family of Amun’s high priests. Due to the briefness of his term and limited surviving records, many details of his life remain uncertain to Egyptologists.